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Computational Biology 101

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Submitted by Paul Tiffany (not verified) on Sun, 11/01/2009 - 07:23

Introduction
Undergraduate research in computational science can facilitate and finance undergraduate educations.  With access to a University's resources, including an internet connection, undergraduates can analyse scientific data to find new connections.
This study closely follows a prior study, for reliability testing with old datasets and the potential to discover new understanding of the affect of caloric restriction with new datasets.  

Methods
Methods can be found beginning on page two of the original study, "Identifying the Genes and Genetic Interrelationships Underlying the Impact of Calorie Restriction on Maximum Lifespan: An Artificial Intelligence-Based Approach." 

Materials
Download
openbiomind here
. Command list
here
.
Below I've compiled a list of studies on the effects of calorie restriction, found on the Gene Aging Nexus.

Edwards MG, Anderson RM, Yuan M, Kendziorski CM et al. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics 2007 Mar 23;8:80.
-Caloric restriction effect on aged skeletal muscle(GDS 2612)

-Expression Profile of Aging and CR Retardation, Hippocampus
-Expression Profile of Aging and CR Retardation, Neocortex [Ben and Lucio used parts of this study in the original paper]

Lustig A, Weeraratna AT, Wood WW 3rd, Teichberg D et al. Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus. Cell Immunol 2007 Jan;245(1):42-61. PMID: 17499630
Zahn JM, Poosala S, Owen AB, Ingram DK et al. AGEMAP: a gene expression database for aging in mice. PLoS Genet 2007 Nov;3(11):e201. PMID: 18081424
-Male and female thymi response to aging and caloric restriction (A)
-Male and female thymi response to aging and caloric restriction (B)

Unknown study
-microarray profiling of potential calorie restriction mimetics

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